doi: 10.21037/sci.2019.10.06.Stem Cell Therapy Compares Well Against DMTs Safety and efficacy of stem cell therapy for treatment of neural damage in patients with multiple sclerosis. The researchers conclude hematopoietic stem cell and various MSC treatments result in “significant improvements in quality-of-life, neurologic disability, and functional scores,” among patients with MS.īejargafshe MJ, Hedayati M, Zahabiasli S, et al. Studies proposed hematopoietic stem cell transplantation “can prohibit MS disease progression for 4 to 5 years in 70% to 80% of patients.” However, “HNSCs are obtained from brain specimens of several fetal human donors from spontaneous miscarriages that occurred after the eighth week after conception…Due to ethical reasons and the lack of the same opportunity to make these cells, it is difficult to use them,” researchers said.Ī type of stem cell-based therapy developed for the treatment of hematological malignancies like lymphoma and leukemia has been explored in recent investigations. In comparison, human fetal-derived neural stem cells (HNSCs) can be considered one of the best treatments for patients with MS because they are the precursors of neuronal cells. In addition, umbilical cord-derived MSCs are attractive treatment options because they are extracted from easily attainable tissue, absent of any ethical dilemmas. The researchers determined adult adipose tissue stem cells are “one of the most suitable cells for MS treatment.” This is due to the fact that adipose tissue is easy to separate, produces a high volume of cells per unit area, and has relatively inexpensive extraction costs. Clinical studies also found that adipose-derived MSC therapy “is a safe method which improves MS disabilities, such as sexual problems and social activities,” in patients. The injection of bone marrow-derived autologous MSCs has been revealed to improve the disease’s severity, patients’ cognitive functions, and overall quality of life due to the cells’ neuroprotective and anti-inflammatory properties. The review analyzed the safety and efficacy of trials involving stem cells derived from these various sources. Stem cells can be easily isolated from different sources of the body, including peripheral blood, adipose and bone marrow tissues, umbilical cord blood, and placenta. For example, “Upon intravenous injection, MSCs are able to traffic into the brain lesions and improve the survival rate of brain cells.” Results also revealed that injection of MSCs decreases disease severity and improves quality of life in patients with MS. “MSCs are multipotent cells with high proliferative and self-renewal capacities, as well as immunomodulatory and neuroregenerative effects,” the researchers said.Īlthough the underlying cellular and molecular mechanisms of stem cell therapy in patients with MS is not understood, tirals have yielded encouraging results. However, clinical trial results point to the safety and efficacy of certain MSC therapies in modulating immune responses in patients with MS. Currently, there is no curative method for MS, nor is there an approved method for improvement of disease progression by repairing the damaged myelin. One of the main symptoms of myelin dysfunction is neurological disabilities. Patients develop MS when autoantibodies target the self-myelin antigens, causing demyelination. Several clinical trials have found mesenchymal stem cell (MSC) therapy effective in treating neural damage in patients with multiple sclerosis (MS), according to a review published in Stem Cell Investigation.
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Once the crust is cooled I put a greek yogurt cheesecake mixture on top and then topped it with a beautiful array of fresh berries!īasically it’s a gorgeous, light, refreshing dessert that you HAVE to make this summer! It’s perfect for a fancy night when you have friends over or a great dish to bring for your next BBQ. The good news is, it turned out awesome the second time and I was even able to make the crust gluten free by using almond flour. And that my friends is why I don’t like baking. This tart was a “love project” for me, I had envisioned how beautiful this thing was going to look in photos but had to make it a couple times because the crust fell apart the first time I made it. Now that you know how awesome my weekend was, it’s time for you to know how amazing this Berry Tart is! Then my sweet husband took me on a shopping spree at the Galleria mall, walked into every store I wanted to go into and bought me all the things! It was awesome! Best weekend ever! Love that man. I highly recommend that place too! Great coffee served with fresh local ingredients with a farm to table concept! It was called the Dish Societyand also super delicious. Woke up late the next morning (to us that’s 8am) and headed to a new brunch place downtown. So yummy and absolutely perfect with our bone-in Filet and scalloped potatoes layered with gouda and caramelized onions! (totally drooling as I type that)Īfter we had dinner, we stayed the night downtown. For a nice date night this place was the bomb! Plus I tried a new wine, Faust, it was still a Cabernet (because that’s my favorite) but was a collection of that grape from different vineyards in the Napa Valley area. If you live in the Houston area you need to go! And actually they have a location in the Chicago area and in Arizona (although in Arizona it’s called Steak 44). They want your first bite to be at warm as your last! Y’all not only was the restaurant trendy and cute when we walked in but the food was absolutely incredible! When they serve the steak they give you a 500 degree F plate to eat it on. So I went to good old Yelp and searched for the top rated steak restaurants near the area we were staying. We always end up feeling like we got to try a good portion of the menu and not overly stuffed. We pick an appetizer, a salad, a side dish and then a main dish. Usually the way Mike and I dine out, we end up splitting everything. I was really in the mood for a glass of wine, some seafood and a good quality steak … basically a nice dinner. I got everything set for the kids, packed myself and started to think of which restaurant I’d like to go to. Pick a restaurant to go to downtown Houston because we’re having a date night followed by a day date.Get Cason ready to stay the night with his cousins.You need to get Maddie ready to stay the night with your mom.You have a few small tasks that need to be done this morning. Walked into our master bathroom and there was a note on the mirror. He knows me very well, I’m a words of affirmation person and a quality time person. Woohoo! But Friday morning, after a long night with Maddie, I woke up to a fun surprise.Įvery once in a while, my husband will write a sweet note on our bathroom mirror. Well if you follow me on Instagram, you know that I had one fun weekend! This beautiful Berry Tart is a light dessert that’s perfect for the summer! Gluten Free Berry Tart filled with a creamy greek yogurt cheesecake filling and an Almond Crust. It’s a classic, isn’t it? Yes, we believe it will always be!Īll you need is some Painter’s tape to create hopscotch for your little ones to hop through. You can plan your obstacle course however you like or even look for some online ideas, including this one. Then do a couple of jumping jacks, shoot a sock or two in the laundry basket and walk from the kitchen or living room to the nearest bedroom while balancing a book on your head – err, or something similar – you get the idea! Get on all fours and crawl underneath the kitchen or dining room table. Now we’re talking! If you want to up the adventure factor by a few notches, then here are some awesome ideas: Grab some snacks and comfy blankets, and take your smartphone or tablet along for a family-friendly movie while everybody snuggles and enjoys the indoor adventure. All you need to do is drape some sheets over the couch or a similar object and pretend you’re getting all cosy somewhere in the woods! You can either set up a tent or come up with a DIY one. With this one, we can get really creative. Between the pause-resume transition, children need to stop dancing and freeze in the position they are in.Įasily among the most fun rainy day activities – good times indeed, keep a camera handy! The great indoors (camping) It’s a great way to pacify restless children and get their sillies out! Play some fun music on the stereo and pause it, then resume it. It’s true: no toddler or pre-schooler can say no to a freeze dance. The participants keep on adding to what the previous ones have already added, until the list gets so massive that no one can remember all the items!įor example: the first player says “I’m going on a picnic in the rain and bringing hot chocolate” – the second player says “I’m going on a picnic in the rain and bringing hot chocolate and an umbrella” – and so on. Let’s begin with the traditional “Going on a Picnic” game with a twist: rain! Have your little ones take turns as they add the items they would love to bring on a picnic while it’s raining. Rainy day activities Let’s go on a picnic (rain version!) If you’re looking for some rainy day activities to keep the children occupied and entertained, here are some of our most fun and creative ideas. Children have a lot of energy so it can be stressful trying to burn this off when confined to the indoors! This happens more often than not since it feels like it’s always raining in Wales! However, we have a few clever tricks up our sleeves. To complete a wire transfer, the sender must provide his bank name and account number of the recipient, the receiving account number, the city and state of the receiving bank and the bank's routing number. New Horizons Credit Union 2. ABA routing number 262175867 is used to facilitate ACH funds transfers. It is used for domestic or international transactions in which no cash or check exchange is involved, but the account balance is directly debited electronically and the funds are transferred to another account in real time. New Horizons Credit Union Branch Location at 7146 Stone Dr, Daphne, AL 36526 - Hours of Operation, Phone Number, Services, Address, Directions and Reviews. Routing number 262175867 is assigned to NEW HORIZONS CREDIT UNION located in MOBILE, AL. ACH Routing Numbers are used for direct deposit of payroll, dividends, annuities, monthly payments and collections, federal and state tax payments etc.įedwire Routing Number: Fedwire Transfer service is the fastest method for transferring funds between business account and other bank accounts. The last number is called as a check digit number which is a confirmation number. The next four numbers identify the specific bank. The first four digits identify the Federal Reserve district where the bank is located. ACH routing number is a nine digit number. Banks offer ACH services for businesses who want to collect funds and make payments electronically in batches through the national ACH network. Explore member reviews for New Horizons Credit Unions Daphne Branch at 7146 Stone Drive, Daphne AL. ACH helps to improves payment processing efficiency and accuracy, and reduce expenses. This routing number is used for electronic financial transactions in the United States. Routing numbers may differ depending on where your account was opened and the type of transaction made.Įach routing number is unique to a particular bank, large banks may have more than one routing number for different states.ĪCH Routing Number: ACH Routing Number stands for Automated Clearing House (ACH). This number identifies the financial institution upon which a payment is drawn. New Horizons is federally insured by the NCUA and is an Equal Housing Lender, offering Solutions for the Real World. Our ATMs are conveniently located at credit union branches, shopping centers, and retail locations across the country. The ABA routing number is a 9-digit identification number assigned to financial institutions by The American Bankers Association (ABA). New Horizons Credit Union offers a vast network of ATMs for its members to access their accounts and perform financial transactions on-the-go. ABA Routing Number: Routing numbers are also referred to as "Check Routing Numbers", "ABA Numbers", or "Routing Transit Numbers" (RTN). Convenient outlet- no need to run extension cords all over the place, just use the one on the table.Assembly/glue up table- glue scrapes up cleanly and oh so satisfyingly!.Using a projector you can adjust the sizes of your design instantly- no math, no trips to the Print shop, no cutting printer paper and taping it together.Then spray several thin coats of frosted finish paint. Easy clean-up: sweep the top and wipe it with some Windex. Step 1: use the white table top to mark on your acrylic sheet the corners that need to be notched out.No need to buy expensive color forms if you have something you can use at home already. For the colors we used take and toss cup lids. Use a router or table saw to cut two grooves into each panel. Glue the edging to one edge of each plywood panel. From matching solid hardwood, cut two pieces of edging measuring 3/4 x 3/4 x 28 in. The grain direction should be parallel to the 15-in. Write measurements directly onto the glass, draw, make lists, use white board markers for quick brainstorming or sharpies for more permanent marks. You will need a clear plastic container with lid, some wax paper, a strand of white christmas lights, scissors and tape. thick hardwood plywood panels measuring 15 x 28 in.Cutting anything with a X-Acto knife is very quick and does not damage the glass.Now the next thing it to piece together the permanent parts (marked in red in the pic), to do so use the regular tape, apply it from both sides. Soldering on the light table is very safe, the light table does not absorb any heat from the soldering iron, and any solder that falls immediately solidifies on contact with the glass. The first thing it to apply the cooking paper to the three sides with the windows, tape it as tight as you can so the light will be distributed evenly.Able to set glass on top of the pattern and cut directly on the light table, no need to cut pieces of paper and glue it to the glass. Check out my New Merchandise Here Thanks.
PDFpen is $59.95 and PDFpenPro is $99.95, with reduced upgrade pricing and various multi-license packs and site licenses available. PDFpen and PDFpenPro 5.7 for Mac OS X are free updates for registered owners of version 5 and require Mac OS X 10.7.2. NOTE: You will also receive an email with your serial number. Your name and serial number will automatically register the product. To buy from within the product itself: 1. I am currently working on our asset inventory and the information I only have is the serial number. PDFpen for iPad sells for $9.99 and requires iOS 5. PDFpenPro (Nitro PDF Pro for Mac) supports rapid editing and modification of PDF files, such as adding text. There are a few ways to buy PDFpen/Pro: Buy PDFpen or PDFpenPro now from here. 173,969 points Enzo28 Said: ' Mac Specs via Serial number: Hi, Thank you for your response. The thumbnail view sidebar makes it easy to skim documents, which can also be copied, combined, and renamed. PDFs can be annotated with comments, highlighting and drawing tools. With PDFpen for iPad, users can add text, images, and signatures to PDFs, make corrections, resize and delete images, and fill out forms. iCloud support is automatically included in the new PDFpen 5.7 and PDFpenPro 5.7 released to the Mac App Store, and users who update to the new version directly via Smile can buy the US$0.99 app PDF Cloud Access at the Mac App Store to receive the new functionality. Remember: you have to log in to to the my. portal using your JHSPH email account credentials to view this information.Smile on Wednesday announced iCloud support for its PDF editor PDFpen, which is also available now for iPad. If you aren't enrolled in a degree program at the School, or aren't School faculty or staff, you can't take advantage of this site license.įor more information on acquiring either PDF Pen Pro or PDF Annotator, please see this page in the my. portal. This makes this tool available for free to all full- and part-time students, faculty, and staff here at the School. Find answers to the following questions: To search the FAQ please enter a search term: I have more than one computer. Recently, JHSPH Information Systems announced that they have acquired a site license for PDF Pen Pro, an equivalent to PDF Annotator for the Mac. Those of us using a Mac could use Preview, an application built in to the Mac OS, to do basic PDF annotation, but Preview lacks many of the features of PDF Annotator. Unfortunately, PDF Annotator is only available for the Windows operating system. the issue using FileMaker Pro Advanced 14.0.5 under Mac OS X 10.11.4. If we don't find a license with that email address, it's possible you didn't purchase with that one, so try a few others. I had originally thought this problem was because I had PDF Pen Pro as my default. This is a really useful tool if you're trying to take class notes digitally or otherwise doing collaborative work using PDF files. Enter your email address into the 'Find My License' field in our serial number lookup. Last Spring, JHSPH Information Systems announced that they had acquired a site license for PDF Annotator, a tool that lets you annotate (write, draw, highlight, and otherwise mark up) PDF files. Another PDF Annotation Tool Available for Full and Part-Time Students The thyroid gland controls the metabolism. Hypothyroidism is a condition that causes the thyroid gland to be underactive. This is often done at the same time as the spay/neuter. In other words, surgery can be performed to secure the stomach in the right position to prevent GDV from occurring. To prevent GDV, a prophylactic gastropexy can be performed. To repair this condition, surgery is required to return the stomach to the right location and secure it in place (gastropexy). Initially, fluid therapy, oxygen therapy, and decompression of the stomach may be performed. The longer a dog has this condition without intervention, the greater the risk of death. Immediate veterinary intervention is needed to stabilize and treat GDV. Increased risk is seen in older dogs that have a deep chest (like the Boxer), are fed from elevated bowls, and are fed only once per day. If not treated quickly, shock, tissue damage, and even death can occur. The stomach can then rotate, which causes inadequate blood supply to the spleen and stomach. This occurs when the stomach fills up with food or gas, causing expansion and increased pressure. Gastric Dilatation-Volvulus (a severe form of bloat in dogs) is a condition that occurs suddenly and requires immediate life-saving intervention. Gastric Dilatation-Volvulus (“Bloat,” GDV) ARVC is treated using medications that control the abnormal heart rhythm (antiarrhythmics). Many Boxers with ARVC live several years before developing symptoms. The normal heart muscle is replaced by fatty and fibrous tissue which causes abnormal electrical activity and therefore irregular heart rhythm. Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC or “Boxer Arrhythmia”)Īrrhythmogenic right ventricular cardiomyopathy is a genetic disease that affects the Boxer dog breed and, rarely, other breeds. Discussion with a veterinarian regarding the risks/benefits of feeding grain-free diets to Boxers is recommended. Vasodilators: to dilate the blood vesselsĪ correlation between DCM and grain-free diets has been found but is not fully understood. Pimobendan: to lower vascular pressure and increase muscle strengthĭiuretics: to remove excess fluid from the bodyĪCE inhibitors: to lower blood pressure and resistanceĬardiac glycosides: to slow the heart rate DCM can eventually lead to congestive heart failure.ĭCM is a very serious condition that requires intensive treatment and not all dogs will return to normal. The symptoms of the disease may occur suddenly or progress gradually as the disease worsens over time. Dilated Cardiomyopathy (DCM)ĭilated cardiomyopathy (DCM) is degeneration of the heart that causes the muscle of the left ventricle to become very thin and pump weakly. It is important to recognize that treatment is generally only recommended by veterinary oncologists for as long as quality of life can be maintained. Chemotherapy, immunotherapy, and/or radiation therapy may be recommended. Referral for consultation with a boarded veterinary oncologist is recommended. Surgery is often used to remove the affected tissue. Talk with your vet to learn the risks and benefits of early spaying for your dog.ĭepending on the type of cancer that a Boxer develops, treatments may vary. Spaying prior to the first heat cycle substantially decreases the risk of developing mammary cancer in adulthood. Mast cell tumors (which can be on the skin or internal organs)Ĭanine lymphoma (a cancer of the lymph nodes and lymph system) CancersĬancers are some of the most common health conditions seen in Boxers. Boxer Dog Health Issuesīoxers are predisposed to a few health conditions including cancer, heart disease, and joint problems. Their high energy and spirited nature typically make Boxers good pets for the active household.īoxers are prone to health issues, so it is important to talk with your veterinarian and have a strong preventative health routine in place. They have a prominent lower jaw and a short nose, which makes them sensitive to overheating. In the past, many Boxers had their ears cropped, but this trend has grown less popular in recent years. They are considered a medium-sized dog breed-weighing in around 65-80 pounds with an average height of 21-23 inches. The Boxer dog breed is deep-chested and is usually well-muscled under its smooth coat. Interestingly, in 2005, a Boxer’s DNA was used to sequence the canine genome. The Boxer is used today by the police and military. This history means they are excellent runners and playful jumpers. They were used for bull-baiting and to chase wild game. The Boxer as it is known today was imported to the United States from Germany in the 1930s. In 20, TeamViewer users reported having their bank accounts emptied by hackers, starting a backlash against this still-popular tool. Choosing Software Like TeamViewerĪfter enjoying a few years as the remote management software for MSPs, a revolt against TeamViewer is beginning to take shape. Dameware simply offers more features and ease of use around controlling and monitoring devices remotely than any other item on the list, and provides greater security than TeamViewer is apparently able to furnish its users. That last option is what I would recommend to most IT or MSP folks looking for a comprehensive solution for remote management. I’ve evaluated a total of nine different software solutions that could potentially replace TeamViewer as a remote management tool for managed service providers: Mikogo, Splashtop, Chrome Remote Desktop,, VNC Connect, Webex Meetings, LogMeIn Pro, DWService, and the Dameware ® Remote Support and Dameware Remote Everywhere solutions. There are plenty of top TeamViewer alternatives available to them, and I think many of them are similar or even superior to TeamViewer in at least one crucial category of value. Though TeamViewer is still a very useful solution with plenty of helpful functionalities, it’s in the best interest of any IT team to consider all the options at their disposal. TeamViewer long enjoyed the advantage of being the primary remote management software solution in IT, but complaints about the high price point and a series of worrisome hacks have left many seeking out alternatives. “We also have an ecosystem that will be ready to support the LR Electric models. “We have a proven fully electric powertrain engineered inside a proven vehicle that integrates well with the body equipment required for collection,” said Jonathan Randall, senior vice president of North American sales and commercial operations for Mack Trucks. All accessories on the Mack LR Electric model are electrically driven through 12V, 24V and 600V circuits. The truck features four NMC lithium-ion batteries (lithium nickel manganese cobalt oxide) that are charged via a 50kW, SAE J1772-compliant charging system. A two-speed Mack Powershift transmission harnesses that power and puts it to the ground through Mack’s S522R 52,000-lb. Specs for the truck include two 130-kW motors that deliver a combined 496 peak HP and 4,051 lb.-ft. The LR Electric is based on Mack’s existing LR refuse truck, but with an electric battery and motors taking the place of the typical diesel engine. Our customers share our values for a cleaner safer fleet that is better for the environment.” “We want to take a leadership role in electrification,” said Shane Walker, area president for the Mid-Atlantic region at Republic Services. The truck will go into service for Republic in Hickory, N.C. Republic Services has a fleet of more than 16,000 trucks that operates in 41 states. Morning Call reporter Jon Harris can be reached at 61 or at. Who knows what technology Mack and others will be rolling out by the time they become old-timers. While DiRico has long since left his first job in the department turning wrenches, his two sons now work there - one as a warehouse manager, the other as a mechanic. The department plans to base the Mack LR Electric at its Brooklyn North 1 garage and test it on a local collection route, evaluating operating range, payload capacity and braking performance. Based on current technology, Tam said, a battery would weigh around 20,000 pounds to be capable of long-haul application, which would sacrifice payload.Īs for DiRico, he said he can’t wait to get the Mack electric truck - with a copper-colored Bulldog hood ornament on the front - back to the city to show it off, already envisioning an event featuring the truck on Earth Day in April. Tam said virtually all truck manufacturers in the domestic market are developing at least one electric model, cutting their teeth on the technology and learning the existing capabilities.Ī larger challenge, Tam said, will be in long-haul trucks, which could be one of the last segments to see battery electric vehicles because of the battery requirements for lengthy journeys. In the refuse industry, he added, the trucks also return to the garage every night, making it easy to recharge. That also leads to less wear and tear on the brakes, which could help reduce operating costs for customers, Horton said. The Mack electric truck has two-stage regenerative braking, in which the operator lifts their foot off the gas pedal to stop the vehicle while the kinetic energy lost during deceleration is converted to stored energy in the battery. Roy Horton, Mack’s director of product strategy, went over several of those reasons Thursday.įor one, Horton said, garbage trucks are constantly starting and stopping during their run. Mack’s MP®8 Engine Finish pump jobs faster with up to 505 available horsepower in the legendary MP8. Mack Trucks showed its Mack LR Electric, its first fully electric refuse model at the Mack Customer Center in Allentown Thursday. mDRIVE HD Optional 13- and 14-speed creeper gears help maximize fuel efficiency and ease driver fatigue. Steve Tam, vice president of Americas Commercial Transportation Research Co., said about 60% of the vehicles in the refuse industry are powered by natural gas, though electric could make sense, too. “That grows over time as the technology becomes more and more commercially viable.” “At some point, a portion of what we build is going to be combustion-diesel and a portion is going to be electric,” Randall said. Once Mack and its customers are comfortable with the product, following some likely adjustments and tweaks, that’s when the company would look at producing the truck at the assembly plant in Lower Macungie Township, he said. Randall said a second truck will go into service later this year with waste giant Republic Services. The New York City Department of Sanitation will be Mack’s first customer to test the electric truck. The first electric truck, Randall said, was put together at the Mack Customer Center in conjunction with the company’s engineers in North Carolina. Mack Trucks showed its Mack LR Electric, its first fully electric refuse model at the Mack Customer Center in Allentown Thursday. |